Trisomy 13 and Massive Fetomaternal Hemorrhage
نویسندگان
چکیده
This is the first case report of trisomy 13 complicated by massive fetomaternal hemorrhage (FMH). A pale male infant weighing 2,950 g was delivered with low Apgar scores by emergency cesarean section due to non-reassuring fetal status. The umbilical arterial pH and hemoglobin level were 6.815 and 6.9 g/dL (normal: 13 - 22 g/dL), respectively. The maternal hemoglobin-F and serum alpha-fetoprotein levels were 6.0% (normal: < 1.0%) and 1,150 ng/mL (4.1 multiple of median), respectively. The neonate was diagnosed as having trisomy 13 by a subsequent chromosome examination. In the placenta, massive intervillous thrombosis was observed microscopically. This placental finding has been reported to be associated with both preeclampsia and massive FMH. In addition, the incidence of preeclampsia in pregnancies complicated by trisomy 13 has been reported to be significantly higher than normal karyotype populations. Therefore, the current finding may support the association between trisomy 13 and the incidence of massive FMH.
منابع مشابه
Prenatal diagnosis of acute massive fetomaternal hemorrhage.
We present here 2 cases of acute and 2 cases of chronic massive fetomaternal hemorrhage. A sinusoidal fetal heart rate pattern may indicate chronic fetomaternal hemorrhage, but, when increased variability is observed in fetal monitoring, maternal hemoglobin F should be measured to exclude acute fetomaternal hemorrhage.
متن کاملMassive fetomaternal hemorrhage secondary to a non-metastatic intraplacental choriocarcinoma SWISS SOCIETY OF NEONATOLOGY
متن کامل
Management of neonatal anemia in the delivery room.
Anemia in ihe newborn can result from many causes. Fetomaternal transfusion is one of them and occurs commonly during pregnancy. It can range from small hemorrhage leading to mild anemia to massive amount with circulatory collapse in the neonate. Chronic fetomaternal transfusion leads to anemia or occasionally hydrops fetails. It is not an emergency as is an acute hemorrhage. We report a case w...
متن کاملTwo intrauterine rescue transfusions in treatment of severe fetomaternal hemorrhage in the early third trimester
KEY CLINICAL MESSAGE When massive fetomaternal hemorrhage is diagnosed in the early third trimester of pregnancy, serial fetal intravascular transfusion may be an alternative to immediate delivery.
متن کاملUsing middle cerebral artery peak systolic velocity to time in utero transfusions in fetomaternal hemorrhage.
BACKGROUND Fetomaternal hemorrhage is a rare cause of fetal anemia and hydrops fetalis. Early and severe fetomaternal hemorrhage may benefit from in utero transfusion(s); however, hemorrhage rate is unpredictable, and reliable criteria are needed to identify recurrent anemia. CASE Fetal hydrops due to massive fetomaternal hemorrhage was diagnosed at 29 weeks. After the first in utero transfus...
متن کامل